A MINI REVIEW OF NATURAL ANTIOXIDANT FOR ALZHEIMER’S DISEASE

Abstract

Alzheimer's disease (AD) is the leading cause of dementia, an estimated 5 million people in the US suffer at a cost
of more than $70 billion per year. The main theories on the causes of AD include amyloid-beta (Aβ), tauopathy,
inflammation and oxidative stress. The purpose of writing this review article is to look at the various types of
natural antioxidants and the mechanism of action of each against AD therapy. Method: this article reviews
antioxidants to activity of action againts AD. The following databases were searched from their inception: Google
scholar, Science direct, PubMed. The document relevant analyzed and included in the review. Therefore, this paper
mainly focuses on the recent developments of common used antioxidant therapies for AD. Results: Alzheimer's
disease correlates with free radicals which can be minimized by consuming natural antioxidants from foods such
as vitamins C and E, carotenoids (β-carotene and astaxanthin), Flavonoids, Green tea, Huperzine, Ginko biloba,
Centella asiatica, Curcumin, Melissa officinalis, Polygala tenuifolia, Salvia miltiorrhiza bung and
Withaniasomnifera (L), with a variety of different mechanisms of action for each of these types of natural
antioxidants. Conclusion: The therapeutic potential of AD in natural antioxidants plays an important role in
prevention and treatment